Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring | Zendy

Matthew Darby | Zendy; Alisha Chetty | Zendy; Dunja Mrjden | Zendy; Marion Rolot | Zendy; Katherine A. Smith | Zendy; Claire Mackowiak | Zendy; Delphine Sedda | Zendy; Donald Nyangahu | Zendy; Heather B. Jaspan | Zendy; KaiMichael Toellner | Zendy; Ari Waisman | Zendy; Valérie Quesniaux | Zendy; Bernhard Ryffel | Zendy; Adam F. Cunningham | Zendy; Benjamin G Dewals | Zendy; Frank Brombacher | Zendy; William Horsnell | Zendy

Open Access

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Author(s) -

Matthew Darby,

Alisha Chetty,

Dunja Mrjden,

Marion Rolot,

Katherine A. Smith,

Claire Mackowiak,

Delphine Sedda,

Donald Nyangahu,

Heather B. Jaspan,

KaiMichael Toellner,

Ari Waisman,

Valérie Quesniaux,

Bernhard Ryffel,

Adam F. Cunningham,

Benjamin G Dewals,

Frank Brombacher,

William Horsnell

Publication year - 2019

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.aav3058

Subject(s) - offspring , helminths , immunity , helminth infections , biology , immunology , pregnancy , medicine , immune system , genetics

Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (T2) impaired IL-4Rα offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived T2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.

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