Helicobacter pylori –induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis | Zendy

Yi-pin Lv | Zendy; Ping Cheng | Zendy; Jinyu Zhang | Zendy; Fang-yuan Mao | Zendy; Yongsheng Teng | Zendy; Yugang Liu | Zendy; Hui Kong | Zendy; Xiaolong Wu | Zendy; Chuan-jie Hao | Zendy; Bin Han | Zendy; Qiang Ma | Zendy; Shiming Yang | Zendy; Weisan Chen | Zendy; Liusheng Peng | Zendy; Tingting Wang | Zendy; Quanming Zou | Zendy; Yuan Zhuang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Helicobacter pylori –induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis

Author(s) -

Yi-pin Lv,

Ping Cheng,

Jinyu Zhang,

Fang-yuan Mao,

Yongsheng Teng,

Yugang Liu,

Hui Kong,

Xiaolong Wu,

Chuan-jie Hao,

Bin Han,

Qiang Ma,

Shiming Yang,

Weisan Chen,

Liusheng Peng,

Tingting Wang,

Quanming Zou,

Yuan Zhuang

Publication year - 2019

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.aau6547

Subject(s) - helicobacter pylori , inflammation , gastritis , matrix metalloproteinase , gastric mucosa , immune system , colonization , biology , immunology , microbiology and biotechnology , stomach , biochemistry , genetics

The interaction between gastric epithelium and immune response plays key roles in -associated pathology. We demonstrated a procolonization and proinflammation role of MMP-10 in infection. MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by and IL-22 via the ERK pathway. Human gastric MMP-10 was correlated with colonization and the severity of gastritis, and mouse MMP-10 from non-BM-derived cells promoted bacteria colonization and inflammation. colonization and inflammation were attenuated in IL-22, MMP-10, and IL-22MMP-10 mice. MMP-10-associated inflammation is characterized by the influx of CD8 T cells, whose migration is induced via MMP-10-CXCL16 axis by gastric epithelial cells. Under the influence of MMP-10, Reg3a, E-cadherin, and zonula occludens-1 proteins decrease, resulting in impaired host defense and increased colonization. Our results suggest that MMP-10 facilitates persistence and promotes gastritis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research