Open AccessPorphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
Author(s) -
Stephen S. Dominy,
Casey Lynch,
Florian Ermini,
Małgorzata Benedyk,
Agata Marczyk,
Andrei W. Konradi,
Mai Nguyen,
Ursula Haditsch,
Debasish Raha,
Christina Griffin,
Leslie J. Holsinger,
Shirin ArastuKapur,
Samer E. Kaba,
Alexander Lee,
Mark I. Ryder,
Barbara Potempa,
Piotr Mydel,
Annelie Hellvard,
Karina Adamowicz,
Hatice Hastürk,
Glenn D. Walker,
Eric C. Reynolds,
Richard L. M. Faull,
Maurice A. Curtis,
Mike Dragunow,
Jan Potempa
Publication year - 2019
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.aau3333
Subject(s) - porphyromonas gingivalis , disease , alzheimer's disease , causation , medicine , biology , neuroscience , pathology , periodontitis , philosophy , epistemology
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.
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