Radical chain repair: The hydroalkylation of polysubstituted unactivated alkenes | Zendy

Guillaume Povie | Zendy; Sankar Rao Suravarapu | Zendy; Martin P. Bircher | Zendy; Melinda Meyer Mojzes | Zendy; Samuel Rieder | Zendy; Philippe Renaud | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Radical chain repair: The hydroalkylation of polysubstituted unactivated alkenes

Author(s) -

Guillaume Povie,

Sankar Rao Suravarapu,

Martin P. Bircher,

Melinda Meyer Mojzes,

Samuel Rieder,

Philippe Renaud

Publication year - 2018

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.aat6031

Subject(s) - scope (computer science) , process (computing) , chemistry , radical , business , computer science , risk analysis (engineering) , biochemical engineering , combinatorial chemistry , organic chemistry , engineering , programming language

The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chemistry, can be used in a radical chain reaction to enable notoriously intractable transformations. By overcoming the radical chain inhibitor properties of substituted alkenes, the radical-mediated hydroalkylation of mono-, di-, tri-, and even tetrasubstituted unactivated olefins could be performed under mild conditions. With a remarkable functional group tolerance, this reaction provides a general coupling method for the derivatization of olefin-containing natural products.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research