Open AccessPromiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia
Author(s) -
S. Picaud,
Katharina Leonards,
JeanPhilippe Lambert,
Oliver M. Dovey,
Christopher Wells,
Oleg Fedorov,
Octovia Monteiro,
Takao Fujisawa,
Chenyi Wang,
Hannah Lingard,
C. Tallant,
Nikzad Nikbin,
Lucie Guetzoyan,
Richard J. Ingham,
Steven V. Ley,
Paul E. Brennan,
Susanne Müller,
Anastasia Samsonova,
AnneClaude Gingras,
Juerg Schwaller,
George S. Vassiliou,
Stefan Knapp,
P. Filippakopoulos
Publication year - 2016
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.1600760
Subject(s) - bromodomain , biology , transcription factor , leukemia , computational biology , transcription (linguistics) , genetics , gene , epigenetics , linguistics , philosophy
BET bromodomains are unique targeting modules that mediate primary transcription response.
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