HOX s and lincRNAs: Two sides of the same coin | Zendy

Bony De Kumar | Zendy; Robb Krumlauf | Zendy

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HOX s and lincRNAs: Two sides of the same coin

Author(s) -

Bony De Kumar,

Robb Krumlauf

Publication year - 2016

Publication title -

science advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.928

H-Index - 146

ISSN - 2375-2548

DOI - 10.1126/sciadv.1501402

Subject(s) - hox gene , coding (social sciences) , computational biology , biology , evolutionary biology , computer science , genetics , gene , mathematics , transcription factor , statistics

The clustered Hox genes play fundamental roles in regulation of axial patterning and elaboration of the basic body plan in animal development. There are common features in the organization and regulatory landscape of Hox clusters associated with their highly conserved functional roles. The presence of transcribed noncoding sequences embedded within the vertebrate Hox clusters is providing insight into a new layer of regulatory information associated with Hox genes.

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