The Emerging Role of Cables1 in Cancer and Other Diseases | Zendy

Jia-Rong Huang | Zendy; Guangmou Tan | Zendy; Yong Li | Zendy; Zhi Shi | Zendy

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The Emerging Role of Cables1 in Cancer and Other Diseases

Author(s) -

Jia-Rong Huang,

Guangmou Tan,

Yong Li,

Zhi Shi

Publication year - 2017

Publication title -

molecular pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.469

H-Index - 198

eISSN - 1521-0111

pISSN - 0026-895X

DOI - 10.1124/mol.116.107730

Subject(s) - cyclin dependent kinase , kinase , signal transducing adaptor protein , biology , phosphorylation , tyrosine kinase , cancer , microbiology and biotechnology , signal transduction , cancer research , cell cycle , genetics

Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and β -catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases.

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