Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences | Zendy

Paula G. Slater | Zendy; Héctor E. Yarur | Zendy; Katia Gysling | Zendy

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Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences

Author(s) -

Paula G. Slater,

Héctor E. Yarur,

Katia Gysling

Publication year - 2016

Publication title -

molecular pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.469

H-Index - 198

eISSN - 1521-0111

pISSN - 0026-895X

DOI - 10.1124/mol.116.104927

Subject(s) - receptor , neuroscience , biology , chemistry , computational biology , biochemistry

The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein-coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and their associated functional consequences. A better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders.

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