UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation | Zendy

Eduardo R. Lazarowski | Zendy; T. Kendall Harden | Zendy

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UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y₁₄ Receptor Activation

Author(s) -

Eduardo R. Lazarowski,

T. Kendall Harden

Publication year - 2015

Publication title -

molecular pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.469

H-Index - 198

eISSN - 1521-0111

pISSN - 0026-895X

DOI - 10.1124/mol.115.098756

Subject(s) - extracellular , receptor , microbiology and biotechnology , glycosylation , signal transduction , cell signaling , g protein coupled receptor , immune system , p2y receptor , chemistry , p2 receptor , biochemistry , biology , immunology , purinergic receptor

UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor, a G-protein-coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.

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