Nonlinear ultrasound parameter to monitor cell death in cancer cell samples | Zendy

Pauline Muleki-Seya | Zendy; Cédric Payan | Zendy; Laure Balasse | Zendy; Régine Guillermin | Zendy; Sandrine Roffino | Zendy; Benjamin Guillet | Zendy; Émilie Franceschini | Zendy

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Nonlinear ultrasound parameter to monitor cell death in cancer cell samples

Author(s) -

Pauline Muleki-Seya,

Cédric Payan,

Laure Balasse,

Régine Guillermin,

Sandrine Roffino,

Benjamin Guillet,

Émilie Franceschini

Publication year - 2018

Publication title -

the journal of the acoustical society of america

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.619

H-Index - 187

eISSN - 1520-8524

pISSN - 0001-4966

DOI - 10.1121/1.5066348

Subject(s) - nonlinear system , scaling , subtraction , binary number , apoptosis , cancer , cancer cell , mathematics , statistics , biological system , physics , medicine , biology , geometry , arithmetic , quantum mechanics , biochemistry

A scaling subtraction method was proposed to analyze the radio frequency data from cancer cell samples exposed to an anti-cancer drug and to estimate a nonlinear parameter. The nonlinear parameter was found to be well correlated (R= 0.62) to the percentage of dead cells in apoptosis and necrosis. The origin of the nonlinearity may be related to a change in contacts between cells, since the nonlinear parameter was well correlated to the average total coordination number of binary packings (R≥ 0.77). These results suggest that the scaling subtraction method may be used to early quantify chemotherapeutic treatment efficiency.

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