Cavitation-enhanced delivery of macromolecules into an obstructed vessel | Zendy

Bassel Rifai | Zendy; Costas D. Arvanitis | Zendy; Miriam BazánPeregrino | Zendy; Constantin Coussios | Zendy

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Cavitation-enhanced delivery of macromolecules into an obstructed vessel

Author(s) -

Bassel Rifai,

Costas D. Arvanitis,

Miriam BazánPeregrino,

Constantin Coussios

Publication year - 2010

Publication title -

the journal of the acoustical society of america

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.619

H-Index - 187

eISSN - 1520-8524

pISSN - 0001-4966

DOI - 10.1121/1.3496388

Subject(s) - cavitation , drug delivery , penetration (warfare) , ultrasound , macromolecule , materials science , biomedical engineering , therapeutic ultrasound , nanotechnology , chemistry , radiology , medicine , mechanics , biochemistry , physics , operations research , engineering

Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring.

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