Microbubble tunneling in gel phantoms | Zendy

Charles F. Caskey | Zendy; Shengping Qin | Zendy; Paul A. Dayton | Zendy; Katherine W. Ferrara | Zendy

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Microbubble tunneling in gel phantoms

Author(s) -

Charles F. Caskey,

Shengping Qin,

Paul A. Dayton,

Katherine W. Ferrara

Publication year - 2009

Publication title -

the journal of the acoustical society of america

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.619

H-Index - 187

eISSN - 1520-8524

pISSN - 0001-4966

DOI - 10.1121/1.3097679

Subject(s) - microbubbles , bubble , materials science , ultrasound , ultrasonic sensor , drug delivery , ultrasonic imaging , acoustics , imaging phantom , pressure wave , modulus , acoustic radiation force , biomedical engineering , mechanics , optics , nanotechnology , composite material , physics , medicine

Insonified microbubbles were observed in vessels within a gel with a Young's modulus similar to that of tissue, demonstrating shape instabilities, liquid jets, and the formation of small tunnels. In this study, tunnel formulation occurred in the direction of the propagating ultrasound wave, where radiation pressure directed the contact of the bubble and gel, facilitating the activity of the liquid jets. Combinations of ultrasonic parameters and microbubble concentrations that are relevant for diagnostic imaging and drug delivery and that lead to tunnel formation were applied and the resulting tunnel formation was quantified.

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