Acoustic response from adherent targeted contrast agents | Zendy

Shukui Zhao | Zendy; Dustin E. Kruse | Zendy; Katherine W. Ferrara | Zendy; Paul A. Dayton | Zendy

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Acoustic response from adherent targeted contrast agents

Author(s) -

Shukui Zhao,

Dustin E. Kruse,

Katherine W. Ferrara,

Paul A. Dayton

Publication year - 2006

Publication title -

the journal of the acoustical society of america

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.619

H-Index - 187

eISSN - 1520-8524

pISSN - 0001-4966

DOI - 10.1121/1.2364303

Subject(s) - microbubbles , contrast (vision) , molecular imaging , ultrasound , materials science , biomedical engineering , acoustics , ultrasonic sensor , computer science , physics , medicine , biology , artificial intelligence , microbiology and biotechnology , in vivo

In ultrasonic molecular imaging, encapsulated micron-sized gas bubbles are tethered to a blood vessel wall by targeting ligands. A challenging problem is to detect the echoes from adherent microbubbles and distinguish them from echoes from nonadherent agents and tissue. Echoes from adherent contrast agents are observed to include a high amplitude at the fundamental frequency, and significantly different spectral shape compared with free agents (p <0.0003). Mechanisms for the observed acoustical difference and potential techniques to utilize these differences for molecular imaging are proposed.

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