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Measurements were undertaken to determine the unknown microbubble-size distribution of a dodecafluoropentane (DDFP) emulsion consisting of 10(12) droplets/ml in surfactant-stabilized water. The acoustic backscatter of 2-microsecond-duration tonebursts of 30-MHz focused ultrasound was measured from the emulsion as it moved in a coaxial flow. Calibration for the system was accomplished using 3-mu m-radius polystyrene spheres, using a linear scattering model and literature values for polystyrene. Applying viscous linear scattering theory to the backscatter data from individual DDFP bubbles allowed inversion of the radius-backscatter relation. A mean microbubble radius of 130 nm was inferred for the DDFP population. (C) 2005 Acoustical Society of America.

Characterization of individual submicron perfluorocarbon gas bubbles by ultrasonic backscatter