Open AccessIntegrated visualization of multi-angle bioluminescence imaging and micro CT
Author(s) -
P. Kok,
Jouke Dijkstra,
Charl P. Botha,
Frits H. Post,
Eric L. Kaijzel,
Ivo Que,
Clemens W.G.M. Löwik,
Johan H. C. Reiber,
Boudewijn P. F. Lelieveldt
Publication year - 2007
Publication title -
proceedings of spie, the international society for optical engineering/proceedings of spie
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.192
H-Index - 176
eISSN - 1996-756X
pISSN - 0277-786X
DOI - 10.1117/12.711117
Subject(s) - visualization , computer science , projection (relational algebra) , computer vision , data visualization , image registration , artificial intelligence , computer graphics (images) , image (mathematics) , algorithm
This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.
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