Demonstration of structural alterations in experimental corneal infectious model using multiphoton microscopy | Zendy

Wen Lo | Zendy; HsinYuan Tan | Zendy; Yuh-Ling Chang | Zendy; Yen Sun | Zendy; SungJan Lin | Zendy; ShiouHwa Jee | Zendy; ChenYuan Dong | Zendy

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Demonstration of structural alterations in experimental corneal infectious model using multiphoton microscopy

Author(s) -

Wen Lo,

HsinYuan Tan,

Yuh-Ling Chang,

Yen Sun,

SungJan Lin,

ShiouHwa Jee,

ChenYuan Dong

Publication year - 2007

Publication title -

proceedings of spie, the international society for optical engineering/proceedings of spie

Language(s) - English

Resource type - Conference proceedings

SCImago Journal Rank - 0.192

H-Index - 176

eISSN - 1996-756X

pISSN - 0277-786X

DOI - 10.1117/12.699468

Subject(s) - autofluorescence , microscopy , cornea , multiphoton fluorescence microscope , materials science , optics , biomedical engineering , biophysics , fluorescence microscope , pathology , biology , medicine , fluorescence , physics

The aim of this study is to assess the application of multiphoton autofluorescence and second harmonic generation (SHG) microscopy for investigating the structural alterations and the pattern of microbial spreading during corneal infectious process in an in vitro organ culture model. The autofluorescence spectrum derived from pathogens allows us to monitoring the pattern of microbial spreading within corneal lamellae. In addition, the destruction and regeneration of second harmonic generating collagen during infectious process can also be monitored in a non-invasive fashion. Therefore we propose that multiphoton microscopy may potentially be applied as an effective monitoring tool for corneal infection studies.

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