Advances in the development of a novel method to be used in proteomics using gold nanobeads
Author(s) -
Heidelinde R. C. Dietrich,
Ian T. Young,
Yuval Garini
Publication year - 2006
Publication title -
proceedings of spie, the international society for optical engineering/proceedings of spie
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.192
H-Index - 176
eISSN - 1996-756X
pISSN - 0277-786X
DOI - 10.1117/12.645908
Subject(s) - computer science , nanotechnology , proteomics , dna , light scattering , process (computing) , sequence (biology) , computational biology , scattering , chemistry , materials science , physics , biology , optics , gene , biochemistry , operating system
The study of DNA-protein interactions is gaining increased attention due to their importance in cellular processes. Only a well-functioning interaction guaranties that such a process can take place without errors. So far, only a small percentage of these interactions have been unraveled, partially due to their complexity but also due to the fact that there are only a few techniques that permit the study of these interactions. In this report we describe the development of a research tool based on tethered bead motion and Resonance Light Scattering (RLS) from gold beads. This method permits the study of DNA-protein interactions and the screening of proteins binding to a specific DNA sequence.
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