Adaptation of nanoarrays for the study of α-synuclein aggregation: preliminary results | Zendy

Heidelinde R. C. Dietrich | Zendy; R. L. van den Doel | Zendy; Wolfgang Hoyer | Zendy; Wim van Oel | Zendy; Guus Liqui Lung | Zendy; Yuval Garini | Zendy; Thomas M. Jovin | Zendy; Ian Young | Zendy

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Adaptation of nanoarrays for the study of α-synuclein aggregation: preliminary results

Author(s) -

Heidelinde R. C. Dietrich,

R. L. van den Doel,

Wolfgang Hoyer,

Wim van Oel,

Guus Liqui Lung,

Yuval Garini,

Thomas M. Jovin,

Ian Young

Publication year - 2005

Publication title -

proceedings of spie, the international society for optical engineering/proceedings of spie

Language(s) - English

Resource type - Conference proceedings

SCImago Journal Rank - 0.192

H-Index - 176

eISSN - 1996-756X

pISSN - 0277-786X

DOI - 10.1117/12.587493

Subject(s) - computer science , adaptation (eye) , miniaturization , protein aggregation , nanotechnology , materials science , chemistry , neuroscience , biology , biochemistry

In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein α-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications.

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