Whole organic electronic synapses for dopamine detection | Zendy

Martina Giordani | Zendy; Michele Di Lauro | Zendy; Marcello Berto | Zendy; Carlo Augusto Bortolotti | Zendy; D. Vuillaume | Zendy; Henrique L. Gomes | Zendy; Michèle Zoli | Zendy; Fabio Biscarini | Zendy

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Whole organic electronic synapses for dopamine detection

Author(s) -

Martina Giordani,

Michele Di Lauro,

Marcello Berto,

Carlo Augusto Bortolotti,

D. Vuillaume,

Henrique L. Gomes,

Michèle Zoli,

Fabio Biscarini

Publication year - 2016

Publication title -

proceedings of spie, the international society for optical engineering/proceedings of spie

Language(s) - English

Resource type - Conference proceedings

SCImago Journal Rank - 0.192

H-Index - 176

eISSN - 1996-756X

pISSN - 0277-786X

DOI - 10.1117/12.2239532

Subject(s) - dopamine , neuroscience , computer science , psychology

A whole organic artificial synapse has been fabricated by patterning PEDOT:PSS electrodes on PDMS that are biased in frequency to yield a STP response. The timescale of the STP response is shown to be sensitive to the concentration of dopamine, DA, a neurotransmitter relevant for monitoring the development of Parkinson's disease and potential locoregional therapies. The sensitivity of the sensor towards DA has been validated comparing signal variation in the presence of DA and its principal interfering agent, ascorbic acid, AA. The whole organic synapse is biocompatible, soft and flexible, and is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids. This may open applications in chronic neurodegenerative diseases such as Parkinson's disease

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