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Towards multimodal detection of melanoma thickness based on optical coherence tomography and optoacoustics
Author(s) -
Maik Rahlves,
Arthur Varkentin,
Jenny Stritzel,
E. Blumenroether,
Mikhail Mazurenka,
Merve MeinhardtWollweber,
Bernhard Roth
Publication year - 2016
Publication title -
proceedings of spie, the international society for optical engineering/proceedings of spie
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.192
H-Index - 176
eISSN - 1996-756X
pISSN - 0277-786X
DOI - 10.1117/12.2213132
Subject(s) - optical coherence tomography , histopathology , computer science , penetration depth , melanoma , biomedical engineering , coherence (philosophical gambling strategy) , materials science , optics , radiology , pathology , medicine , physics , cancer research , quantum mechanics
Melanoma skin cancer has one of the highest mortality rates of all types of cancer if not detected at an early stage. The survival rate is highly dependent on its penetration depth, which is commonly determined by histopathology. In this work, we aim at combining optical coherence tomography and optoacoustic as a non-invasive all-optical method to measure the penetration depth of melanoma. We present our recent achievements to setup a handheld multimodal device and also results from first in vivo measurements on healthy and cancerous skin tissue, which are compared to measurements obtained by ultrasound and histopathology. © 2016 SPIE

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