Open AccessHeritability analysis of surface-based cortical thickness estimation on a large twin cohort
Author(s) -
Kaikai Shen,
Vincent Doré,
Stephen Rose,
Jürgen Fripp,
Katie L. McMahon,
Greig I. de Zubicaray,
Nicholas G. Martin,
Paul M. Thompson,
Margaret J. Wright,
Olivier Salvado
Publication year - 2015
Publication title -
proceedings of spie, the international society for optical engineering/proceedings of spie
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.192
H-Index - 176
eISSN - 1996-756X
pISSN - 0277-786X
DOI - 10.1117/12.2081677
Subject(s) - precuneus , superior frontal gyrus , heritability , cortex (anatomy) , inferior frontal gyrus , gyrus , inferior parietal lobule , superior parietal lobule , cerebral cortex , population , neuroscience , posterior parietal cortex , anatomy , audiology , psychology , medicine , biology , cognition , genetics , environmental health
The aim of this paper is to assess the heritability of cerebral cortex, based on measurements of grey matter (GM) thickness derived from structural MR images (sMRI). With data acquired from a large twin cohort (328 subjects), an automated method was used to estimate the cortical thickness, and EM-ICP surface registration algorithm was used to establish the correspondence of cortex across the population. An ACE model was then employed to compute the heritability of cortical thickness. Heritable cortical thickness measures various cortical regions, especially in frontal and parietal lobes, such as bilateral postcentral gyri, superior occipital gyri, superior parietal gyri, precuneus, the orbital part of the right frontal gyrus, right medial superior frontal gyrus, right middle occipital gyrus, right paracentral lobule, left precentral gyrus, and left dorsolateral superior frontal gyrus
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