Open AccessNon-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography
Author(s) -
David AlonsoCaneiro,
Masahiro Yamanari,
Shinichi Fukuda,
Sujin Hoshi,
Satoko Nagase,
Tetsuro Oshika,
Yoshiaki Yasuno,
Michael J. Collins
Publication year - 2013
Publication title -
proceedings of spie, the international society for optical engineering/proceedings of spie
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.192
H-Index - 176
eISSN - 1996-756X
pISSN - 0277-786X
DOI - 10.1117/12.2002988
Subject(s) - optical coherence tomography , cornea , keratoconus , glutaraldehyde , in situ , materials science , in vivo , ophthalmology , optics , biomedical engineering , ectasia , ex vivo , tomography , medicine , chemistry , pathology , biology , physics , microbiology and biotechnology , organic chemistry
Collagen crosslinking (CXL) has shown promising results in the prevention of the progression of keratoconus and corneal ectasia. However, techniques for in vivo and in situ assessment of the treatment are limited. In this study, ex vivo porcine eyes were treated with a chemical CXL agent (glutaraldehyde), during which polarization sensitive optical coherence tomography (PS-OCT) recordings were acquired simultaneously to assess the sensitivity of the technique to assess changes in the cornea. The results obtained in this study suggest that PS-OCT may be a suitable technique to measure CXL changes in situ and to assess the local changes in the treated region of the cornea
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