Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery | Zendy

Sean Harvey | Zendy; David Y. W. Ng | Zendy; Jolanta Szelwicka | Zendy; Lisa Hueske | Zendy; Lothar Veith | Zendy; Marco Raabe | Zendy; Ingo Lieberwirth | Zendy; George Fytas | Zendy; Katrin Wunderlich | Zendy; Tanja Weil | Zendy

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Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery

Author(s) -

Sean Harvey,

David Y. W. Ng,

Jolanta Szelwicka,

Lisa Hueske,

Lothar Veith,

Marco Raabe,

Ingo Lieberwirth,

George Fytas,

Katrin Wunderlich,

Tanja Weil

Publication year - 2018

Publication title -

biointerphases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.633

H-Index - 45

eISSN - 1934-8630

pISSN - 1559-4106

DOI - 10.1116/1.5042640

Subject(s) - polyethylene glycol , peg ratio , nanoparticle , surface modification , chemistry , aqueous solution , nanotechnology , copolymer , chemical engineering , drug delivery , dendrimer , polymer chemistry , materials science , polymer , organic chemistry , finance , engineering , economics

Very small polydopamine (PDA) polyethylene glycol (PEG) crosslinked copolymer (PDA-PEG) nanoparticles have been prepared following a convenient one-step procedure in aqueous solution. Particle sizes and colloidal stabilities have been optimized by varying PEG in view of chain length and end group functionalities. In particular, amine-terminated PEG3000 [PEG(NH)] reacted with polydopamine intermediates so that very small, crosslinked PDA-PEG nanoparticles with sizes of less than 50 nm were formed. These nanoparticles remained stable in buffer solution and no sedimentation occurred. Chemical functionalization was straight-forward as demonstrated by the attachment of fluorescent dyes. The PDA-PEG nanoparticles revealed efficient cellular uptake via endocytosis and high cytocompatibility, thus rendering them attractive candidates for cell imaging or for drug delivery applications.

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