Tip-enhanced Raman scattering of DNA aptamers for Listeria monocytogenes | Zendy

Siyu He | Zendy; Hongyuan Li | Zendy; Carmen L. Gomes | Zendy; Dmitri V. Voronine | Zendy

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Tip-enhanced Raman scattering of DNA aptamers for Listeria monocytogenes

Author(s) -

Siyu He,

Hongyuan Li,

Carmen L. Gomes,

Dmitri V. Voronine

Publication year - 2018

Publication title -

biointerphases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.633

H-Index - 45

eISSN - 1934-8630

pISSN - 1559-4106

DOI - 10.1116/1.5022303

Subject(s) - aptamer , biosensor , raman scattering , raman spectroscopy , listeria monocytogenes , molecular biophysics , nanotechnology , nanoscopic scale , chemistry , dna , image resolution , materials science , optics , physics , biology , biochemistry , bacteria , microbiology and biotechnology , genetics

Optical detection and conformational mapping of aptamers are important for improving medical and biosensing technologies and for better understanding of biological processes at the molecular level. The authors investigate the vibrational signals of deoxyribonucleic acid aptamers specific to Listeria monocytogenes immobilized on gold substrates using tip-enhanced Raman scattering (TERS) spectroscopy and nanoscale imaging. The authors compare topographic and nano-optical signals and investigate the fluctuations of the position-dependent TERS spectra. They perform spatial TERS mapping with 3 nm step size and discuss the limitation of the resulting spatial resolution under the ambient conditions. TERS mapping provides information about the chemical composition and conformation of aptamers and paves the way to future label-free biosensing.

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