Gold nanoparticles increases UV and thermal stability of human serum albumin | Zendy

Robin Capomaccio | Zendy; Inês Osório | Zendy; Isaac OjeaJiménez | Zendy; Giacomo Ceccone | Zendy; Pascal Colpo | Zendy; Douglas Gilliland | Zendy; Rohanah Hussain | Zendy; Giuliano Siligardi | Zendy; François Rossi | Zendy; Sylvie RicardBlum | Zendy; Luigi Calzolai | Zendy

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Gold nanoparticles increases UV and thermal stability of human serum albumin

Author(s) -

Robin Capomaccio,

Inês Osório,

Isaac OjeaJiménez,

Giacomo Ceccone,

Pascal Colpo,

Douglas Gilliland,

Rohanah Hussain,

Giuliano Siligardi,

François Rossi,

Sylvie RicardBlum,

Luigi Calzolai

Publication year - 2016

Publication title -

biointerphases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.633

H-Index - 45

eISSN - 1934-8630

pISSN - 1559-4106

DOI - 10.1116/1.4972113

Subject(s) - colloidal gold , nanoparticle , irradiation , ultraviolet , bovine serum albumin , chemistry , denaturation (fissile materials) , ultraviolet irradiation , ultraviolet radiation , thermal stability , albumin , human serum albumin , biophysics , nanotechnology , materials science , nuclear chemistry , chromatography , optoelectronics , biochemistry , radiochemistry , organic chemistry , physics , biology , nuclear physics

Ultraviolet (UV) radiation, temperature, and time can degrade proteins. Here we show that gold nanoparticles significantly protect human serum albumin (HSA) from denaturation when exposed to “stressing” conditions such as UV irradiation and sustained exposure in sub-optimal conditions. In particular, we show that gold nanoparticles significantly reduce the decrease in secondary structure induced by UV irradiation or extended exposure to ambient temperature.JRC.F.2-Consumer Products Safet

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