Fibroblast adhesion on unidirectional polymeric nanofilms | Zendy

Christof Christophis | Zendy; Koray Sekeroglu | Zendy; Gökhan Demirel | Zendy; I. Thomé | Zendy; M. Grunze | Zendy; Melik C. Demirel | Zendy; Axel Rosenhahn | Zendy

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Fibroblast adhesion on unidirectional polymeric nanofilms

Author(s) -

Christof Christophis,

Koray Sekeroglu,

Gökhan Demirel,

I. Thomé,

M. Grunze,

Melik C. Demirel,

Axel Rosenhahn

Publication year - 2011

Publication title -

biointerphases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.633

H-Index - 45

eISSN - 1934-8630

pISSN - 1559-4106

DOI - 10.1116/1.3646093

Subject(s) - filopodia , adhesion , laminar flow , wetting , nanotechnology , anisotropy , materials science , cell adhesion , fibroblast , microfluidics , rod , biophysics , chemistry , composite material , cell , optics , mechanics , physics , biochemistry , biology , in vitro , medicine , alternative medicine , pathology

Nanotextured polymeric surfaces with inclined rods reveal highly anisotropic properties concerning wetting and adhesion. In this work, we report on the interaction of fibroblast cells with these highly anisotropic materials. The authors quantified removal of adherent cells from such surfaces by a laminar flow. The critical shear force needed for cell removal from the surface depends on the inclination direction. Based on electron microscopy cross sections we deduce that interactions of cellular filopodia extending into the nanotextured surface are causing the direction depending removal.

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