Continuum model of mechanical interactions between biological cells and artificial nanostructures | Zendy

Piyush Verma | Zendy; Ian Y. Wong | Zendy; Nicholas A. Melosh | Zendy

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Continuum model of mechanical interactions between biological cells and artificial nanostructures

Author(s) -

Piyush Verma,

Ian Y. Wong,

Nicholas A. Melosh

Publication year - 2010

Publication title -

biointerphases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.633

H-Index - 45

eISSN - 1934-8630

pISSN - 1559-4106

DOI - 10.1116/1.3431960

Subject(s) - indentation , nanostructure , clamping , deformation (meteorology) , biological cell , nanotechnology , work (physics) , biophysics , mechanics , continuum mechanics , materials science , biological system , classical mechanics , physics , composite material , mechanical engineering , engineering , thermodynamics , biology

The controlled insertion of artificial nanostructures into biological cells has been utilized for patch clamping, targeted drug delivery, cell lysing, and cell mechanics measurements. In this work, an elastic continuum model is implemented to treat the deformation of spherical cells in solution due to their interaction with cylindrical probes. At small deformations, the force varies nonlinearly with indentation due to global deformation of the cell shape. However, at large indentations, the force varies linearly with indentation due to more localized deformations. These trends are consistent with experimental measurements under comparable conditions and can be used to develop design rules for optimizing probe-cell interactions.

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