Open AccessEffect of Film Formation Method and Annealing on Crystallinity of Poly(L-Lactic Acid) Films
Author(s) -
ShanTing Hsu,
Y. Lawrence Yao
Publication year - 2011
Publication title -
citeseer x (the pennsylvania state university)
Language(s) - English
Resource type - Conference proceedings
DOI - 10.1115/msec2011-50205
Subject(s) - crystallinity , materials science , annealing (glass) , fourier transform infrared spectroscopy , lamellar structure , chemical engineering , intermolecular force , spin coating , polymer , solvent , lactic acid , optical microscope , composite material , coating , organic chemistry , chemistry , scanning electron microscope , molecule , biology , bacteria , engineering , genetics
Poly(L-lactic acid) (PLLA) has been shown to have potential medical usage such as in drug delivery because it can degrade into bioabsorbable products in physiological environments, and its degradation is affected by crystallinity. In this paper, the effect of film formation method and annealing on the crystallinity of PLLA are investigated. The films are made through solvent casting and spin coating methods, and subsequent annealing is conducted. The resulting crystalline morphology, structure, conformation, and intermolecular interaction are examined using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. It is observed that solvent casting produces category 1 spherulites while annealed spin coated films leads to spherulites of category 2. Distinct lamellar structures and intermolecular interactions in the two kinds of films have been shown. The results enable better understanding of the crystallinity in PLLA, which is essential for its drug delivery application.Copyright © 2011 by ASME
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