Toward the Development of Novel Nitric Oxide Donating Polymeric Materials to Improve the Biocompatibility of Implanted Devices | Zendy

Elizabeth A. Moore | Zendy; Megan C. Frost | Zendy

Open Access

Toward the Development of Novel Nitric Oxide Donating Polymeric Materials to Improve the Biocompatibility of Implanted Devices

Author(s) -

Elizabeth A. Moore,

Megan C. Frost

Publication year - 2010

Publication title -

journal of medical devices

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.242

H-Index - 29

eISSN - 1932-619X

pISSN - 1932-6181

DOI - 10.1115/1.3443738

Subject(s) - biocompatibility , nitric oxide , absorbance , aqueous solution , oxide , combinatorial chemistry , chemistry , nuclear chemistry , nanotechnology , materials science , organic chemistry , chromatography

Previous studies have shown that many S-nitrosothiols (RSNOs) rapidly degrade, with half-lives from minutes to seconds in aqueous solution [1]. The research presented in this paper presents data that the RSNO 1,3-benzenedinitrosothiol has been relatively stable for over 1 year. This RSNO still releases nitric oxide (NO) when subjected to ultraviolet light and has the same characteristic absorbance peak as a freshly made RSNO. Developing this stable RSNO potentially provides a venue for further investigation into using this NO donor to improve the biocompatibility of implanted optical sensors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research