Biotransport Special Issue

Important applications of bioheat and mass transfer include bioreservation molecular, cellular and tissue and thermal therapies high temperature—laser, radiofrequency, microwave, high intenity ultrasound heating of cells and tissues, and low temperature— ryosurgery . These applications in turn support the growing fields f tissue engineering, cell therapeutics, drug stability and delivery, nd minimally and non-invasive disease detection and treatment i.e., cancer, cardiovascular and neural . The frontiers of bioreservation and thermal therapies are increasingly defined at the ellular and molecular level. This special issue focuses on these rontiers in areas of emphasis including thermodynamics molecuar and cellular stability , multi-scale mass transport sub-cellular o tissue level transport , multi-scale heat transport nanoparticle o bulk tissue heating , and extreme biology anhydro and thermal hysiology . The papers assembled in this special issue show the readth of this activity with a series of invited reviews and origial contributions in the area. The special issue is organized into two main sections. The first ection is composed of a number of invited reviews and the secnd section includes a series of contributed technical briefs and apers that are broadly in the current and evolving areas of emhasis in Biotransport. The reviews were invited to show activity oth within and outside of ASME. First, Aksan et al. present a eview entitled “Frontiers of Biotransport: Water Transport and ydration,” which describes a molecular level approach to bioreservation and thermal therapies, followed by Shen et al. with a eview entitled “Insights Into Crowding Effects on Protein Stabilty From a Coarse-Grained Model,” which probes changes in hyration of proteins relevant to biopreservation. In describing ulti-scale mass transport, Pangburn et al. offer a review entitled Peptide and Aptamer Functionalized Nanovectors for Targeted elivery of Therapeutics,” and Masamoto and Tanishita present a eview of challenges in measuring “Oxygen Transport in Brain issue.” Day et al. present a topical review of “Nanoparticles for hermal Cancer Therapy,” and finally Grahn et al. present a reiew of a new paradigm for enhanced heat loss and control in Heat Loss Through the Glabrous Skin Surfaces of Heavily Insuated, Heat-Stressed Individuals.” The remaining papers in the isue consist of both technical briefs and contributed full papers rom a variety of groups showing the breadth of activity mostly ithin the “Biotransport” committee of ASME.