Purified pollen extract and vasomotor symptoms management

Vasomotor symptoms (hot flushes, sweats) are the most frequent problems in menopausal period. Pathophysiology of vasomotor symptoms is based on estrogen decrease, alteration of neurotransmitters levels (serotonin, noradrenalin) and on dysregulation of systemic arterial tree. Hormone Replacement Therapy is a first-line treatment in the management of climacteric syndrome. Other non-hormonal therapies include drugs with central action as Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Noradrenalin Reuptake Inhibitors (SNRIs). A purified pollen extract has demonstrated to improve vasomotor symptoms and quality of life in premenopausal and postmenopausal women in randomized placebo-controlled trials. Its mechanism of action is based on a SSRI-like activity, through the inhibition of serotonin reuptake. rIAssunto: Sintomi vasomotori ed estratto di polline purificato: meccanismo di azione.