Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism | Zendy

Donald N. Cook | Zendy; Hong Soon Kang | Zendy; Anton M. Jetten | Zendy

Open Access

Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism

Author(s) -

Donald N. Cook,

Hong Soon Kang,

Anton M. Jetten

Publication year - 2015

Publication title -

nuclear receptor research

Language(s) - English

Resource type - Journals

eISSN - 2314-5714

pISSN - 2314-5706

DOI - 10.11131/2015/101185

Subject(s) - retinoic acid , circadian rhythm , nuclear receptor , biology , receptor , orphan receptor , immunity , endocrinology , medicine , pharmacology , immune system , immunology , genetics , transcription factor , gene

In this overview, we provide an update on recent progress made in understanding the mechanisms of action, physiological functions, and roles in disease of retinoic acid related orphan receptors (RORs). We are particularly focusing on their roles in the regulation of adaptive and innate immunity, brain function, retinal development, cancer, glucose and lipid metabolism, circadian rhythm, metabolic and inflammatory diseases and neuropsychiatric disorders. We also summarize the current status of ROR agonists and inverse agonists, including their regulation of ROR activity and their therapeutic potential for management of various diseases in which RORs have been implicated.

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