SYNTHESIS AND CHARACTERIZATION OF BENZOHYDROXAMIC ACID METAL COMPLEXES AND THEIR CYTOTOXICITY STUDY | Zendy

Latifah Robbaniyyah Hassan | Zendy; Kalavathy Ramasamy | Zendy; Siong Meng Lim | Zendy; Hadariah Bahron | Zendy; Amalina Mohd Tajuddin | Zendy

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SYNTHESIS AND CHARACTERIZATION OF BENZOHYDROXAMIC ACID METAL COMPLEXES AND THEIR CYTOTOXICITY STUDY

Author(s) -

Latifah Robbaniyyah Hassan,

Kalavathy Ramasamy,

Siong Meng Lim,

Hadariah Bahron,

Amalina Mohd Tajuddin

Publication year - 2018

Publication title -

jurnal teknologi

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.191

H-Index - 22

eISSN - 2180-3722

pISSN - 0127-9696

DOI - 10.11113/jt.v80.12293

Subject(s) - chemistry , denticity , metal , ligand (biochemistry) , cytotoxicity , octahedron , elemental analysis , nuclear chemistry , tetrahedral molecular geometry , inorganic chemistry , octahedral molecular geometry , proton nmr , conductance , carbon 13 nmr , molar ratio , crystallography , stereochemistry , organic chemistry , catalysis , in vitro , crystal structure , biochemistry , receptor , mathematics , combinatorics

Hydroxamic acids (RCONHOH) are versatile compounds that constitute a significant biological importance. The syntheses, physico-chemical and characterization of benzohydroxamic acid (BHA) and its metal complexes (VO(IV), Cr(III) and Ni(II)) are reported herein. The metal complexes were synthesized via condensation reaction of BHA and metal salts in 2:1 molar ratio using ethanol as reaction medium. The compounds were characterized by elemental analysis, spectral (infrared, UV-Vis, 1 H and 13 C NMR,), TGA, magnetic susceptibility as well as molar conductance. The spectral study analysis reveals that all complexes coordinated to the metal via oxygen atoms ( O,O ) in bidentate manner to form octahedral for [Cr(BHA 2 ).2H 2 O]H 2 O, tetrahedral for [Ni(BHA) 2 ] and square pyramidal geometry for [VO(BHA) 2 ]. The molar conductance values suggested that all complexes were non-electrolytes. A cytotoxicity study against HCT116 displayed that VO(IV) has better IC 50 values than the parent ligand, BHA but not considered as potent anticancer agents.

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