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Hydroxamic acids (RCONHOH) are versatile compounds that constitute a significant biological importance. The syntheses, physico-chemical and characterization of benzohydroxamic acid (BHA) and its metal complexes (VO(IV), Cr(III) and Ni(II)) are reported herein. The metal complexes were synthesized via condensation reaction of BHA and metal salts in 2:1 molar ratio using ethanol as reaction medium. The compounds were characterized by elemental analysis, spectral (infrared, UV-Vis, 1 H and 13 C NMR,), TGA, magnetic susceptibility as well as molar conductance. The spectral study analysis reveals that all complexes coordinated to the metal via oxygen atoms ( O,O ) in bidentate manner to form octahedral for [Cr(BHA 2 ).2H 2 O]H 2 O, tetrahedral for [Ni(BHA) 2 ] and square pyramidal geometry for [VO(BHA) 2 ]. The molar conductance values suggested that all complexes were non-electrolytes. A cytotoxicity study against HCT116 displayed that VO(IV) has better IC 50 values than the parent ligand, BHA but not considered as potent anticancer agents.

SYNTHESIS AND CHARACTERIZATION OF BENZOHYDROXAMIC ACID METAL COMPLEXES AND THEIR CYTOTOXICITY STUDY