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Cardiovascular disease still one of the highest death factor in Indonesia. Ginger as an anti-atherosclerosis could be one of the alternatives that is being developed to decrease the cardiovascular disease. The general aims of this research were determining the mechanism of ginger as anti-atherosclerosis to decrease the risk of cardiovascular disease. Research design used was “The Randomized Posttest only Control Group Design”. In this research, the experimental unit was Rattus norvegicus, male; in the age of 3 months and total number were thirty. Independent variable of this research was  steeping of ginger, the dose various of steeping ginger (control, 1g, 3g, 3g + bay leaf, and 5g), and dependent variable was Tumor Necrotic Factor (TNF)α of tissue lipid. TNF α expression was measured by using ELISA method. The data was analyzed by using ANOVA. Based on the analysis, it showed that steeping of ginger was decreased the expression of TNF-α in fat tissue (1g = 551 pg/mL, 3g = 511 pg/mL, 3g + bay leaf = 493 pg /mL) compare to control (986.8 pg/mL) but on the 5 g dose there is contradictory effect that is there is increasing TNF α (1103.5 pg/mL). Conclusion, steeping of ginger potentially decrease the risk of atherosclerosis by attenuate of TNF α expression.

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STEEPING OF GINGER (ZINGIBEROFFICINLAE ROSCOE) POTENTIALLY DECREASE THE RISK OF ATHEROSCLEROSIS BY ATTENUATE OF TUMOR NECROSIS FACTOR (TNF)-α EXPRESSION