Open AccessThe temporal and long‐term impact of donor body mass index on recipient outcomes after kidney transplantation – a retrospective study
Author(s) -
Naik Abhijit S.,
Zhong Yingchao,
Parasuraman Ravi,
Doshi Mona,
Norman Silas,
Lu Yee,
Shaban Eman,
Shahinian Vahakn,
Schaubel Douglas E.
Publication year - 2020
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13505
Subject(s) - medicine , kidney transplantation , term (time) , body mass index , retrospective cohort study , index (typography) , transplantation , nephrology , intensive care medicine , physics , quantum mechanics , world wide web , computer science
Summary The impact of increasing body mass index ( BMI ) on development and progression of chronic kidney disease is established. Even implantation kidney biopsies from obese living donors demonstrate subtle histologic changes despite normal function. We hypothesized that kidneys from obese living ( LD ) and deceased donors ( DD ) would have inferior long‐term allograft outcomes. In a study utilizing US transplant registry, we studied adult kidney transplant recipients from 2000 to 2014. Donors were categorized as BMI <20 (underweight), 20–25 (normal), 25–30 (overweight), 30–35 (mildly obese), and >35 kg/m 2 (very obese). Our outcome of interest was death censored graft failure ( DCGF ). Cox proportional hazards model were fitted separately for recipients of DD and LD kidneys, and adjusted for donor, recipient, and transplant characteristics, including donor and recipient size mismatch ratio. Among 118 734 DD and 84 377 LD transplants recipients, we observed a significant and graded increase in DCGF risk among the overweight ( LD : HR = 1.06, DD : HR = 1.04), mildly obese ( LD : HR = 1.16, DD : HR = 1.10), and very obese ( LD : HR = 1.22, DD : HR = 1.22) compared to normal BMI ( P < 0.05). The graded effect of donor BMI on outcomes begins early and persists throughout the post‐transplant period. Donor obesity status is an independent risk factor for inferior long‐term renal allograft outcome despite adjusting for donor and recipient size mismatch and other donor, recipient, and transplant factors.