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Despite unknown risks, prescription opioid use (POU) for nonmalignant chronic pain has grown in the US over the last decade. The objective of this study was to examine associations between POU and coronary heart disease (CHD), stroke, and cardiovascular disease (CVD) death in a large cohort.

Prescription Opioid Use and Risk of Coronary Heart Disease, Stroke, and Cardiovascular Death among Adults from a Prospective Cohort (REGARDS Study)