Spinal Heme Oxygenase-1 (HO-1) Exerts Antinociceptive Effects Against Neuropathic Pain in a Mouse Model of L5 Spinal Nerve Ligation | Zendy

Xiaoming Liu | Zendy; ZhiJun Zhang | Zendy; Zhuqiang Cheng | Zendy; Jie Zhang | Zendy; Shuangshuang Xu | Zendy; Hongjun Liu | Zendy; Hongbin Jia | Zendy; Yi Jin | Zendy

Open Access

Spinal Heme Oxygenase-1 (HO-1) Exerts Antinociceptive Effects Against Neuropathic Pain in a Mouse Model of L5 Spinal Nerve Ligation

Author(s) -

Xiaoming Liu,

ZhiJun Zhang,

Zhuqiang Cheng,

Jie Zhang,

Shuangshuang Xu,

Hongjun Liu,

Hongbin Jia,

Yi Jin

Publication year - 2015

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1111/pme.12906

Subject(s) - neuropathic pain , copp , medicine , heme oxygenase , spinal cord , microglia , pharmacology , nociception , anesthesia , hyperalgesia , nerve injury , spinal nerve , allodynia , inflammation , heme , chemistry , receptor , biochemistry , psychiatry , enzyme

Heme oxygenase-1 (HO-1) exerts protective effects against ischemia and inflammation in the central nervous system. However, its role in neuropathic pain is still unclear. This study was undertaken to explore the distribution and possible mechanism of HO-1 in a mouse model of peripheral nerve injury.

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