Open AccessNonlinear Effects of Noxious Thermal Stimulation and Working Memory Demands on Subjective Pain Perception
Author(s) -
Sturgeon John A.,
Tieu Meghan M.,
Jastrzab Laura E.,
McCue Rebecca,
Gandhi Vanisha,
Mackey Sean C.
Publication year - 2015
Publication title -
pain medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 97
eISSN - 1526-4637
pISSN - 1526-2375
DOI - 10.1111/pme.12774
Subject(s) - noxious stimulus , stimulation , audiology , perception , psychology , task (project management) , cognition , working memory , intensity (physics) , threshold of pain , medicine , physical medicine and rehabilitation , nociception , anesthesia , neuroscience , physics , receptor , management , quantum mechanics , economics
Objective A bidirectional relationship between working memory (WM) and acute pain has long been assumed, but equivocal evidence exists regarding this relationship. This study characterized the relationship between WM and acute pain processing in healthy individuals using an adapted Sternberg WM task. Design Participants completed a Sternberg task while receiving noxious thermal stimulation. Participants received a pseudorandom presentation of four different temperatures (baseline temperatures and individually determined low‐, medium‐, and high‐temperature stimuli) and four levels of Sternberg task difficulty (0‐, 3‐, 6‐, and 9‐letter strings). Subjects Twenty‐eight healthy participants were recruited from Stanford University and the surrounding community to complete this study. Results A nonlinear interaction between intensity of thermal stimulation and difficulty of the Sternberg task was noted. Increased cognitive load from the Sternberg task resulted in increased perception of pain in low‐intensity thermal stimulation but suppressed pain perception in high‐intensity thermal stimulation. Thermal stimulation had no significant effect on participants' response time or accuracy on the Sternberg task regardless of intensity level. Conclusions Pain perception appears to decrease as a function of WM load only for sufficiently noxious stimuli. However, increasing noxious stimuli did not affect cognitive performance. These complex relationships may reflect a shared cognitive space that can become “overloaded” with input of multiple stimuli of sufficient intensity.