Open AccessNovel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism
Author(s) -
Zempleni Janos,
Liu Dandan,
Teixeira Camara Daniel,
Cordonier Elizabeth L
Publication year - 2014
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/nure.12103
Subject(s) - biotinylation , biotin , biology , biochemistry , hsp60 , heat shock protein , catabolism , gene , microbiology and biotechnology , metabolism , hsp70
The role of holocarboxylase synthetase ( HLCS ) in catalyzing the covalent binding of biotin to the five biotin‐dependent carboxylases in humans is well established, as are the essential roles of these carboxylases in the metabolism of fatty acids, the catabolism of leucine, and gluconeogenesis. This review examines recent discoveries regarding the roles of HLCS in assembling a multiprotein gene repression complex in chromatin. In addition, emerging evidence suggests that the number of biotinylated proteins is far larger than previously assumed and includes members of the heat‐shock superfamily of proteins and proteins coded by the ENO1 gene. Evidence is presented linking biotinylation of heat‐shock proteins HSP 60 and HSP 72 with redox biology and immune function, respectively, and biotinylation of the two ENO1 gene products MBP ‐1 and ENO 1 with tumor suppression and glycolysis, respectively.