Open AccessMechanistic perspective on the relationship between pyridoxal 5'‐phosphate and inflammation
Author(s) -
Paul Ligi,
Ueland Per Magne,
Selhub Jacob
Publication year - 2013
Publication title -
nutrition reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.958
H-Index - 150
eISSN - 1753-4887
pISSN - 0029-6643
DOI - 10.1111/nure.12014
Subject(s) - inflammation , kynurenine , pyridoxal phosphate , catabolism , sphingolipid , pyridoxal , immune system , chemistry , ceramide , metabolism , biochemistry , enzyme , sphingosine 1 phosphate , vitamin , kynurenine pathway , sphingosine , cofactor , biology , tryptophan , immunology , amino acid , receptor , apoptosis
A variety of inflammatory disease conditions have been found to be associated with low levels of plasma pyridoxal 5'‐phosphate ( PLP ), the active form of vitamin B 6 , without any indication of a lower dietary intake of vitamin B 6 , excessive catabolism of the vitamin, or congenital defects in its metabolism. The present review was conducted to examine the existing literature in this regard. Current evidence suggests that the inverse association between plasma PLP and inflammation may be the result of mobilization of this coenzyme to the site of inflammation, for use by the PLP ‐dependent enzymes of the kynurenine pathway of tryptophan degradation, metabolism of the immunomodulatory sphingolipids, ceramide and sphingosine 1‐phosphate, and for serine hydroxymethylase for immune cell proliferation.