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Background  Clinical research suggests that a novel spinal cord stimulation (SCS) waveform, known as Burst‐SCS, specifically targets cognitive‐motivational aspects of pain. The objective of the present study was to assess the cognitive‐motivational aspects of Tonic‐ and Burst SCS‐induced pain relief, by means of exit latency in the mechanical conflict‐avoidance system (MCAS), in a rat model of chronic neuropathic pain.    Methods  Exit latency on the MCAS operant testing setup was evaluated at various probe heights for rats (n = 26) with chronic neuropathic pain induced by a partial sciatic nerve ligation (PSNL). Von Frey paw withdrawal analysis was performed to assess mechanical hypersensitivity. In a second experiment (n = 12), the behavioral effect of Tonic SCS or biphasic Burst SCS on both Von Frey analysis and MCAS exit latency was assessed.    Results  Burst SCS exit latencies differed significantly from Tonic SCS exit latencies at 4 mm probe height (3.8 vs. 5.8 sec, respectively;  p  &lt; 0.01) and 5 mm probe height (3.2 vs. 5.4 sec respectively;  p  &lt; 0.05). This difference was not detected with reflex‐based Von Frey testing (Tonic‐SCS vs. Burst‐SCS at 30 min stimulation:  p  = 0.73, and at 60 min stimulation;  p  = 0.42).    Conclusions  Testing of MCAS exit latency allows for detection of cognitive‐motivational pain relieving aspects induced by either Tonic‐ or Burst‐SCS in treatment of chronic neuropathic rats. Our behavioral findings strongly suggest that Burst‐SCS specifically affects, much more than Tonic‐SCS, the processing of cognitive‐motivational aspects of pain.

Burst and Tonic Spinal Cord Stimulation in the Mechanical Conflict‐Avoidance System: Cognitive‐Motivational Aspects