Open AccessStimVision Software: Examples and Applications in Subcallosal Cingulate Deep Brain Stimulation for Depression
Author(s) -
Noecker Angela M.,
Choi Ki Sueng,
RivaPosse Patricio,
Gross Robert E.,
Mayberg Helen S.,
McIntyre Cameron C.
Publication year - 2018
Publication title -
neuromodulation: technology at the neural interface
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 60
eISSN - 1525-1403
pISSN - 1094-7159
DOI - 10.1111/ner.12625
Subject(s) - deep brain stimulation , depression (economics) , neuroscience , psychology , functional connectivity , computer science , artificial intelligence , medicine , economics , keynesian economics , disease , parkinson's disease
Objective Create a software tool to facilitate tractography‐based deep brain stimulation (DBS) electrode targeting within the patient‐specific stereotactic coordinate system used in the operating room. Approach : StimVision was developed with Visualization Toolkit libraries and integrates four major components: 1) medical image visualization, 2) tractography visualization, 3) DBS electrode positioning, and 4) DBS activation volume calculation with tractography intersection. Results Initial applications of StimVision are focused on the study of subcallosal cingulate (SCC) DBS for the treatment of depression. Retrospective modeling results on SCC DBS have suggested that direct stimulation of a specific collection of tractographic pathways are necessary for therapeutic benefit; thereby creating a tractography‐based DBS surgical targeting hypotheses. StimVision is the tool we created to facilitate prospective clinical evaluation of that hypothesis. Significance Retrospective tractography‐based analyses are common in DBS research; however, intraoperative software tools for interactive selection of a tractography‐based DBS target are not readily available. StimVision provides an academic research tool to assist clinical implementation of new DBS targeting strategies and postoperative evaluation of targeting outcome.