Open AccessDeep Brain Recordings Using an Implanted Pulse Generator in P arkinson's Disease
Author(s) -
Neumann WolfJulian,
Staub Franziska,
Horn Andreas,
Schanda Julia,
Mueller Joerg,
Schneider GerdHelge,
Brown Peter,
Kühn Andrea A.
Publication year - 2016
Publication title -
neuromodulation: technology at the neural interface
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 60
eISSN - 1525-1403
pISSN - 1094-7159
DOI - 10.1111/ner.12348
Subject(s) - deep brain stimulation , local field potential , subthalamic nucleus , parkinson's disease , stimulation , neuroscience , pulse (music) , beta rhythm , medicine , electroencephalography , psychology , computer science , disease , telecommunications , detector
Objectives Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with P arkinson's disease for subthalamic closed‐loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator. Methods Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation ( DBS ). All data were analyzed in the frequency domain using F ourier transform‐based methods and compared between ON and OFF stimulation conditions. Results Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity ( p = 0.002). Conclusion The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed‐loop stimulation in patients with P arkinson's disease.