Deep Brain Recordings Using an Implanted Pulse Generator in  P arkinson's Disease | Zendy

Neumann WolfJulian | Zendy; Staub Franziska | Zendy; Horn Andreas | Zendy; Schanda Julia | Zendy; Mueller Joerg | Zendy; Schneider GerdHelge | Zendy; Brown Peter | Zendy; Kühn Andrea A. | Zendy

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Deep Brain Recordings Using an Implanted Pulse Generator in P arkinson's Disease

Author(s) -

Neumann WolfJulian,

Staub Franziska,

Horn Andreas,

Schanda Julia,

Mueller Joerg,

Schneider GerdHelge,

Brown Peter,

Kühn Andrea A.

Publication year - 2016

Publication title -

neuromodulation: technology at the neural interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.296

H-Index - 60

eISSN - 1525-1403

pISSN - 1094-7159

DOI - 10.1111/ner.12348

Subject(s) - parkinson's disease , pulse (music) , deep brain stimulation , pulse generator , generator (circuit theory) , neuroscience , disease , medicine , psychology , computer science , physics , telecommunications , detector , power (physics) , jitter , quantum mechanics

Objectives Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with P arkinson's disease for subthalamic closed‐loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator. Methods Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation ( DBS ). All data were analyzed in the frequency domain using F ourier transform‐based methods and compared between ON and OFF stimulation conditions. Results Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity ( p = 0.002). Conclusion The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed‐loop stimulation in patients with P arkinson's disease.

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