Open AccessEncapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity
Author(s) -
GutiérrezGutiérrez Filiberto,
SánchezJiménez Cecilia,
RangelCastañeda Itzia Azucena,
CarbajalArízaga Gregorio Guadalupe,
MacíasLamas Adriana Macaria,
CastilloRomero Araceli,
ParraSaavedra Karina Jeanette
Publication year - 2020
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/jphp.13266
Subject(s) - layered double hydroxides , curcumin , chemistry , bioavailability , nuclear chemistry , fourier transform infrared spectroscopy , photodegradation , biocompatibility , solubility , biochemistry , chemical engineering , organic chemistry , pharmacology , adsorption , photocatalysis , medicine , engineering , catalysis
Objectives Curcumin (CUR) has well‐known activity against cancer cells and parasites; however, its applications are limited since this is an unstable molecule, which may suffer degradation by light and temperature, also, the low water solubility reduce its bioavailability. Layered double hydroxides (LDH) are well‐known materials owing to the excellent anion exchange capacity, good biocompatibility and low toxicity. Methods Layered double hydroxides nanoparticles prepared with zinc and magnesium cations were used as a vehicle for CUR in Caco‐2, Giardia lamblia and Entamoeba histolytica cultures. The physicochemical properties of Mg‐LDH‐CUR and Zn‐LDH‐CUR were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FTIR) and X‐ray powder diffraction (XRD). Additionally, the load efficiency, release profiles and photostability of CUR were quantified by high‐performance liquid chromatography (HPLC) and UV‐Vis spectrometry. Then, Mg‐LDH‐CUR and Zn‐LDH‐CUR were tested on Caco‐2, G. lamblia and E. histolytica cultures. Key findings The experiments demonstrated that Zn‐LDH‐CUR protects better against photodegradation by UV light, while Mg‐LDH‐CUR showed increased toxicity against Caco‐2 cell, G. lamblia and E. histolytica , in comparison with free CUR. Conclusions Layered double hydroxides are good vehicles to improve stability, resistance to degradation of CUR, also they are useful to improve solubility, provide a controlled release and improve the cytotoxic activity. Additionally, it was shown that the composition of the M +2 cation of LDH affects its properties and structure and that this directly influences its biological activity. The findings are important to select the composition of the encapsulation vehicle for a specific activity.