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Nerve biopsy in acquired neuropathies
Author(s) -
Sommer Claudia,
Carroll Antonia S,
Koike Haruki,
Katsuno Masahisa,
Ort Nora,
Sobue Gen,
Vucic Steve,
Spies Judith M,
Doppler Kathrin,
Kiernan Matthew C
Publication year - 2021
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns.12464
Subject(s) - medicine , nerve biopsy , biopsy , dermatology , physical medicine and rehabilitation , pathology , peripheral neuropathy , endocrinology , diabetes mellitus
Abstract A diagnosis of neuropathy can typically be determined through clinical assessment and focused investigation. With technological advances, including significant progress in genomics, the role of nerve biopsy has receded over recent years. However, making a specific and, in some cases, tissue‐based diagnosis is essential across a wide array of potentially treatable acquired peripheral neuropathies. When laboratory investigations do not suggest a definitive diagnosis, nerve biopsy remains the final step to ascertain the etiology of the disease. The present review highlights the utility of nerve biopsy in confirming a diagnosis, while further illustrating the importance of a tissue‐based diagnosis in relation to treatment strategies, particularly when linked to long‐term immunosuppressive therapies,