Open AccessPhenotypic features of central sensitization
Author(s) -
Williams David A.
Publication year - 2018
Publication title -
journal of applied biobehavioral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.448
H-Index - 26
eISSN - 1751-9861
pISSN - 1071-2089
DOI - 10.1111/jabr.12135
Subject(s) - endophenotype , sensitization , quantitative sensory testing , psychology , cognition , affect (linguistics) , sensory system , cluster (spacecraft) , clinical psychology , audiology , medicine , neuroscience , computer science , communication , programming language
The current manuscript reviews approaches for phenotyping central sensitization ( CS ). The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.). Each of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions ( COPC s)—conditions likely influenced by CS . Chronic overlapping pain conditions likely represent clinical diagnostic phenotypes of CS . Components of CS can also be assessed using QST or self‐report instruments designed to assess single elements of CS or more general composite indices.