Open AccessParametric simulation of drug release from hydrogel‐based matrices
Author(s) -
Lamberti Gaetano
Publication year - 2012
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.2011.01373.x
Subject(s) - theophylline , parametric statistics , drug , diclofenac , computer science , work (physics) , materials science , finite element method , diclofenac sodium , mathematics , biological system , chemistry , thermodynamics , chromatography , physics , pharmacology , statistics , medicine , biochemistry , biology
Objectives In this work a model recently proposed to describe the drug release from hydrogel‐based matrices was applied to describe the fractional drug release from matrices based on hydroxypropylmethylcellulose (HPMC) and diclofenac. Methods The model, firstly proposed to describe the behaviour of systems based on HPMC and theophylline and a single set of preparation variables, is based on mass balances and transport phenomena evaluation and it was solved by an FEM‐based numerical code. The experimental data on the HPMC–diclofenac matrices, taken from literature, have been obtained by varying the drug loading ratio, the compression force, the powder size of both the drug and the polymer. Key findings A good agreement between experimental data and model predictions, as calculated in the present work, was obtained without the use of any adjustable parameters. Conclusions The predictive nature of the model has been confirmed, even changing the drug molecule and other preparative parameters.