Open AccessRenal Excretion of Vancomycin in Rats with Acute Renal Failure
Author(s) -
NAKAMURA TSUTOMU,
KOKURYO TOSHIYUKI,
TAKANO MIKIHISA,
INUI KENICHI
Publication year - 1997
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.1997.tb06771.x
Subject(s) - renal function , uranyl nitrate , renal physiology , vancomycin , medicine , endocrinology , excretion , clearance , nephrotoxicity , filtration fraction , kidney , urology , chemistry , renal blood flow , biology , bacteria , materials science , uranium , metallurgy , genetics , staphylococcus aureus
We have investigated the renal excretion of vancomycin in rats with acute renal failure (ARF) induced by uranyl nitrate or cisplatin. The renal clearance of the antibiotic after uranyl nitrate or cisplatin injection was separately evaluated by calculating the glomerular filtration rate (GFR) and secretory clearance. The reduced renal clearance of vancomycin in these ARF rats was a result of a decrease in both GFR and secretory clearance. The extents of the decreases in GFR and in secretory clearance were not, however, proportional, the extent of the decrease in secretory clearance being more pronounced. These results suggest that the renal tubular secretion of vancomycin was reduced more predominantly than glomerular filtration in these ARF models.