Open AccessPharmacological Studies on Puerariae flos III: Protective Effects of Kakkalide on Ethanol‐induced Lethality and Acute Hepatic Injury in Mice
Author(s) -
YAMAZAKI TAKASHI,
NAKAJIMA YOSHIJIRO,
NIIHO YUJIRO,
HOSONO TSUYOSHI,
KURASHIGE TATSUO,
KINJO JUNEI,
NOHARA TOSHIHIRO
Publication year - 1997
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.1997.tb06122.x
Subject(s) - ethanol , transaminase , flos , pharmacology , acute toxicity , alcohol , chemistry , liver injury , medicine , toxicity , biochemistry , antioxidant , enzyme , rutin
Kakkalide, one of the major isoflavonoid components of Puerariae flos , has been investigated for its effect on ethanol‐induced intoxication and on hepatic injury, including hyperglycaemia, in mice. Kakkalide reduced mortality associated with administration of ethanol. At doses of 100 and 200 mg kg − the effect of kakkalide was significant. The same dose of kakkalide prevented increased serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activity. At a dose of 200 mg kg − it also counteracted ethanol‐induced elevation of glucose levels. These results suggest that kakkalide might be useful for counteracting the effects of alcohol and might be effective for treating hepatic injury.