Open AccessIndole Alkaloids from Sickingia williamsii Reduce the In‐vitro Effects of Morphine Withdrawal in the Guinea‐pig
Author(s) -
CAPASSO A.,
AQUINO R.,
GAROFALO L.,
SIMONE F.,
SORRENTINO L.
Publication year - 1997
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.1997.tb06097.x
Subject(s) - indole test , guinea pig , morphine , in vitro , ileum , pharmacology , chemistry , biology , traditional medicine , medicine , stereochemistry , biochemistry , endocrinology
The effect of indole alkaloids from Sickingia williamsii Standi. (Rubiaceae) on the effects of morphine withdrawal have been examined in‐vitro. All the indole alkaloids isolated from S. williamsii (10 −4 , 5 ×10 −5 and 10 −5 m ) significantly and in a concentration‐dependent manner reduced the effects of morphine withdrawal on the guinea‐pig ileum. The results suggest that these alkaloids might be potential anti‐addictive agents.